Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Post-operative 5-Fluorouracil for glaucoma surgery.

R Wormald1, M R Wilkins, C Bunce

  • 1Research and Development Department, Moorfields Eye Hospital and Institute of Ophthalmology (UCL), City Road, London, UK, EC1V 2PD. r.wormald@ucl.ac.uk

The Cochrane Database of Systematic Reviews
|November 1, 2001
PubMed
Summary

Post-operative 5-Fluorouracil injections may reduce trabeculectomy failure in glaucoma surgery. However, low doses might be ineffective, and while serious complications are not increased, other adverse events are more common.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SIGNIFIED: whole-body MRI screening in Li-Fraumeni syndrome in the UK.

ESMO open·2026
Same author

Li Fraumeni syndrome in the UK: clinical characteristics and outcomes of TP53 carriers.

ESMO open·2025
Same author

Patient-specific modelling of pulmonary arterial hypertension: wall shear stress correlates with disease severity.

Frontiers in bioengineering and biotechnology·2025
Same author

Whole genome sequencing-powered ctDNA sequencing for breast cancer detection.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Association of post-operative ctDNA detection with outcomes of patients with early breast cancers.

ESMO open·2024
Same author

Differences in the Surgical Outcomes of Glaucoma Surgery in Patients of African Caribbean Descent.

Current eye research·2022

Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Pharmacology

Background:

  • Trabeculectomy is a surgical procedure to reduce intra-ocular pressure in glaucoma.
  • Scar tissue formation can lead to trabeculectomy failure by blocking fluid outflow.
  • Antimetabolites like 5-Fluorouracil (5-FU) are used to inhibit scarring after glaucoma surgery.

Purpose of the Study:

  • To evaluate the effectiveness of post-operative 5-Fluorouracil injections in glaucoma surgery.
  • To assess the impact of 5-FU on preventing surgical failure and complications.

Main Methods:

  • Systematic review of randomized controlled trials comparing post-operative 5-FU injections to placebo or no injections.
  • Searches conducted in CENTRAL, MEDLINE, and EMBASE, with reference list and citation searches.

Related Experiment Videos

  • Data extraction and quality assessment performed independently by two reviewers.

    • Main Results:

    • Nine trials with 614 participants were included; methodological quality was generally low.
    • Post-operative 5-FU injections reduced the likelihood of trabeculectomy failure, especially in high-risk eyes.
    • Low doses of 5-FU may not be effective; other complications increased, though serious sight-threatening ones did not.

    Conclusions:

    • Post-operative 5-FU injections appear effective in preventing trabeculectomy failure but are used less frequently.
    • The increased incidence of non-serious complications may contribute to reduced use.
    • A significant omission in trials was the lack of reporting on patient perspectives regarding this invasive treatment.