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Related Experiment Videos

Single-dose dipyrone for acute postoperative pain.

J E Edwards1, F Meseguer, C C Faura

  • 1Pain Research Unit, Churchill Hospital, Old Road, Headington, Oxford, UK, OX3 7LJ. jayne.edwards@pru.ox.ac.uk

The Cochrane Database of Systematic Reviews
|November 1, 2001
PubMed
Summary

Single-dose dipyrone effectively manages moderate to severe postoperative pain, showing efficacy comparable to other common analgesics. Common side effects include drowsiness and gastrointestinal upset, with no serious adverse events reported in this analysis.

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Area of Science:

  • Pharmacology
  • Pain Management
  • Clinical Trials

Background:

  • Dipyrone is a widely used analgesic in many countries, particularly for postoperative, colic, cancer pain, and migraines.
  • Its use is controversial due to a potential association with serious blood dyscrasias like agranulocytosis, leading to bans in some regions (e.g., USA, UK).

Purpose of the Study:

  • To quantitatively assess the analgesic efficacy of single-dose dipyrone in randomized trials for moderate to severe postoperative pain.
  • To compare dipyrone's efficacy against placebo and other analgesics using a standardized methodology.

Main Methods:

  • Systematic review of published randomized, double-blind, placebo- or active-controlled trials of single-dose dipyrone for postoperative pain.
  • Inclusion criteria focused on adult patients with moderate to severe pain, various administration routes, and double-blind designs.

Related Experiment Videos

  • Data extraction focused on pain relief over 4-6 hours, calculating the proportion of patients achieving at least 50% relief and number-needed-to-treat.

    • Main Results:

    • Fifteen studies were included; eight used placebo and seven used active controls.
    • Single oral doses of dipyrone (500 mg or 1 g) achieved at least 50% pain relief in 69-73% of patients, compared to 20-32% with placebo.
    • Intramuscular dipyrone (2 g) showed a 74% response rate versus 46% for placebo. Efficacy in active-controlled trials was similar to placebo-controlled trials.

    Conclusions:

    • Single-dose dipyrone demonstrates comparable analgesic efficacy to ibuprofen 400 mg and other common analgesics for moderate to severe postoperative pain.
    • The most frequently reported adverse effects were somnolence, gastric discomfort, and nausea.