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Related Experiment Videos

Dopamine agonists for cocaine dependence.

B G Soares1, M S Lima, A A Reisser

  • 1Centro Cochrane do Brasil, Escola Paulista de Medicina UNIFESP, Av. Dr. Altino Arantes, 1132, São Paulo, SP, Brazil, 96100. bgos@zaz.com.br

The Cochrane Database of Systematic Reviews
|November 1, 2001
PubMed
Summary
This summary is machine-generated.

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Dopamine agonists like amantadine and bromocriptine are not effective for treating cocaine dependence. Further research is needed to find better treatments for this public health issue.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Cocaine dependence is a significant public health problem with severe medical, psychological, and social consequences.
  • Chronic cocaine use alters dopamine concentrations in the brain, suggesting dopamine modulation as a potential therapeutic target.
  • Withdrawal symptoms include depression, fatigue, and craving, necessitating effective treatment strategies.

Purpose of the Study:

  • To evaluate the efficacy and acceptability of dopamine agonists in treating cocaine dependence.
  • To synthesize evidence from randomized controlled trials on dopamine agonist therapy for cocaine addiction.

Main Methods:

  • A systematic search of multiple databases (Cochrane, MEDLINE, EMBASE, LILACS, PsycLIT, Biological Abstracts) was conducted.

Related Experiment Videos

  • Included randomized controlled trials focused on dopamine agonists for cocaine dependence, including those with co-occurring opiate dependence.
  • Data extraction included relative risks and weighted mean differences; sensitivity analyses were performed.

    • Main Results:

    • Twelve studies with 587 participants compared dopamine agonists (amantadine, bromocriptine) to placebo or antidepressants.
    • No significant differences were found in efficacy (cocaine metabolite levels) or acceptability (treatment retention) between dopamine agonists and placebo.
    • Results were consistent for participants with primary cocaine dependence and those with additional opioid dependence.

    Conclusions:

    • Current evidence does not support the clinical use of dopamine agonists for treating cocaine dependence.
    • High dropout rates in cocaine-dependent populations suggest the need for supportive psychotherapeutic measures to improve treatment retention.