Related Experiment Video

Updated: Aug 4, 2026

Growth Assays to Assess Polyglutamine Toxicity in Yeast
09:06

Growth Assays to Assess Polyglutamine Toxicity in Yeast

Published on: March 5, 2012

Altered transcription in yeast expressing expanded polyglutamine

R E Hughes1, R S Lo, C Davis

  • 1Division of Medical Genetics, Department of Medicine, University of Washington, Box 357360, Seattle, WA 98195, USA.

Proceedings of the National Academy of Sciences of the United States of America
|November 1, 2001
PubMed
Summary

Expanded polyglutamine tracts cause neurodegenerative diseases. Yeast models show this toxicity involves transcriptional dysregulation, which can be reversed by histone deacetylase inhibitors, suggesting new therapeutic strategies.

More Related Videos

Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity09:21

Saccharomyces cerevisiae Metabolic Labeling with 4-thiouracil and the Quantification of Newly Synthesized mRNA As a Proxy for RNA Polymerase II Activity

Published on: October 22, 2018

Effect of Fluorescent Proteins on Fusion Partners Using Polyglutamine Toxicity Assays in Yeast09:23

Effect of Fluorescent Proteins on Fusion Partners Using Polyglutamine Toxicity Assays in Yeast

Published on: November 28, 2018

Related Concept Videos

Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...