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Oxidative stress in hemodialyzed patients during exhausting exercise
L Jiménez1, G Lefèvre, R Richard
1Département de Physiologie de la Faculté de Médecine Cochin-Port-Royal (Université René Descartes) and Service d'Explorations Fonctionnelles et de Physiopathologie de l'Exercise Centre Hospitalier Cochin-Tarnier, Paris, France. Lijimenez@aol.com
The Journal of Sports Medicine and Physical Fitness
|November 1, 2001
Summary
Physical exercise increases oxidative stress in hemodialyzed patients during recovery, unlike in healthy individuals. Hemodialyzed patients also exhibit lower antioxidant enzyme activity at rest.
Area of Science:
- Exercise physiology
- Biochemistry
- Nephrology
Background:
- Hemodialysis (HD) patients often exhibit increased oxidative stress.
- Lipid peroxidation markers like malondialdehyde (MDA) and vitamin E levels are indicators of oxidative stress.
Purpose of the Study:
- To investigate the effects of an exhaustive exercise test on plasma malondialdehyde (MDA) and vitamin E levels.
- To compare these effects in hemodialyzed patients (HD) versus healthy control subjects (HC).
Main Methods:
- Eight HD patients and eight HC subjects underwent a symptom-limited exercise test.
- Plasma and erythrocyte scavenger enzyme activities (glutathione peroxidase and superoxide dismutase) were measured.
- Blood samples were collected pre-exercise, at exhaustion, and post-recovery.
Main Results:
- HD patients had lower resting scavenger enzyme activity than HC.
- Exercise increased plasma MDA post-recovery in HD patients, while HC showed a decrease.
- Vitamin E levels did not change in HD patients but increased post-exercise in HC.
Conclusions:
- HD patients exhibit reduced antioxidant capacity and experience exercise-induced oxidative stress during recovery.
- Physical exercise may exacerbate oxidative stress in HD patients.
- Healthy individuals show an increase in plasma vitamin E post-exercise, suggesting an adaptive response.