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Assembly of microarrays for genome-wide measurement of DNA copy number

A M Snijders1, N Nowak, R Segraves

  • 1Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA.

Nature Genetics
|November 1, 2001
PubMed

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DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...