[Primary angiitis of CNS (PACNS)]
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Updated: Oct 3, 2026

Isolation and Cannulation of Cerebral Parenchymal Arterioles
Published on: May 23, 2016
J D Rollnik1, A Brandis, K Dehghani
1Medizinische Hochschule Hannover (MHH), Neurologische Klinik mit Klinischer Neurophysiologie, 30623 Hannover. rollnik.jens@mh-hannover.de
Abstract:
Primary angiitis of the CNS (PACNS) is a rare inflammatory disease affecting middle-aged patients. The angiitis is focal and segmental in distribution, involving small and medium-sized leptomeningeal and intracranial vessels. The most frequent presenting symptoms are headaches, focal neurologic deficits, and confusion. In addition, aphasia, neuropsychological deficits, and seizures may occur. The paper presents a review of the literature. In addition, a typical case of PACNS is presented. This case demonstrates that diagnosis of PACNS is difficult and brain biopsy is essential to confirm it.
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