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Updated: Aug 8, 2026
09:07
An Orthotopic Model of Murine Bladder Cancer
Published on: February 6, 2011
Lessons to be learned: a case study approach. Paraganglioma of the urinary bladder
M Dewan1, M Rasshid, E M Elmalik
1Asir Central Hospital, Post Box 34, Abha, Asir Region, Saudi Arabia.
The Journal of the Royal Society for the Promotion of Health
|November 2, 2001
Summary
This case study details a rare urinary bladder paraganglioma in a young woman. Diagnosis involved immunohistochemistry and electron microscopy, highlighting the need for long-term follow-up.
Area of Science:
- Uropathology
- Endocrinology
- Oncology
Background:
- Primary paraganglioma of the urinary bladder is an uncommon tumor.
- Early diagnosis and characterization are crucial for patient management.
Observation:
- A 23-year-old female presented with gross hematuria and a bladder tumor identified via IVU and cystoscopy.
- Hemodynamic instability occurred during transurethral resection.
Findings:
- Histopathology revealed organoid nests of cells consistent with paraganglioma.
- Immunohistochemistry confirmed positivity for chromogranin A, neuron-specific enolase, and S-100 protein.
- Ultrastructural analysis identified neurosecretory granules, confirming the diagnosis.
Implications:
- Currently, no definitive pathological criteria exist to differentiate benign from malignant bladder paraganglioma.
- Adjuvant radiation therapy and mandatory long-term follow-up are recommended due to potential for recurrence and metastasis.
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