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Na+/Li+ exchange kinetic characterization. Red blood cells from normotensive individuals
J L Corchs1, D Taborda, G Mujica
1Department of Physiology, School of Medicine, National University of Rosario, Santa Fe, Argentina. gmujica@citynet.net.ar
Abstract:
The plasma membrane Na+/Li+ exchange is of research interest because it is involved in some pathologic states. A kinetic analysis of this transport system would be of greater importance as compared to the flux determination under "standard" conditions (reactants saturating levels) as a way to define normal values. Unidirectional lithium fluxes in red blood cells from normal adults were determined as a function of "trans" (contralateral) sodium ion concentration. Relating Li+ efflux and influx (Na+ "trans") kinetic parameters we found free carrier reorientation between the two phases (asymmetry).
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