Chronic active myocarditis following acute Bartonella henselae infection (cat scratch disease)

G R Meininger1, T Nadasdy, R H Hruban

  • 1Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA.

Insights

Bartonella henselae infection can cause chronic active myocarditis, leading to severe heart failure. This finding suggests Bartonella should be recognized as a cause of myocarditis.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pathology

Background:

  • Myocarditis is inflammation of the heart muscle.
  • Bartonella henselae is a bacterium known to cause cat scratch disease.
  • A link between Bartonella infection and myocarditis has not been previously established.

Observation:

  • A case study of a young, healthy male patient is presented.
  • The patient developed chronic active myocarditis following Bartonella henselae infection.
  • The condition progressed to severe heart failure.

Findings:

  • Bartonella henselae infection was identified as the cause of chronic active myocarditis in this patient.
  • The patient required an orthotopic heart transplant due to the severity of heart failure.
  • This case demonstrates a novel association between Bartonella henselae and myocardial inflammation.

Implications:

  • Bartonella henselae should be considered in the differential diagnosis of infectious agents causing chronic active myocarditis.
  • Further research is warranted to understand the prevalence and mechanisms of Bartonella-associated myocarditis.
  • This finding may impact clinical guidelines for diagnosing and managing myocarditis, particularly in cases with unclear etiology.

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...