Ambulatory blood pressure in patients with mesangial proliferative glomerulonephritis

Twenty-four-hour ambulatory blood pressure was measured in seven normotensive and 10 hypertensive patients with biopsy proven mesangial proliferative glomerulonephritis (MPG). In normotensive patients, the nocturnal blood pressure variation was seen with a nightly drop in blood pressure while in hypertensive patients with MPG, 24-h blood pressure level was increased both at day- and night-time, but a nocturnal change in blood pressure was also observed in these patients. The pattern of blood pressure variation was not, however, different from the normotensive patients. None of the hypertensive patients with MPG was a so-called non-dipper, showing the same level of blood pressure both at day- and night-time. The hypertensive patients had a rapid increase in blood pressure in the early morning hours from 06.00 to 09.00 h, followed by a relatively abrupt decrease in blood pressure in the evening hours. The patients with high blood pressure were treated with antihypertensive drugs; all patients started with captopril 25 mg once a day, later increasing to twice daily. If the correction of the high blood pressure was not achieved with this drug, amlodipine 5 or 10 mg was added with or without furosemide. Most of the patients needed more than one drug. In all patients, a normal 24-h ambulatory blood pressure could be obtained. The lack of nightly non-dippers in the present hypertensive patients may be explained by a relatively short history of renal disease and the presence of normal or moderately reduced glomerular filtration rate. The abrupt rise in blood pressure during the early morning hours may be due to activation of the renin-angiotensin or sympathetic nervous system in the hypertensive patients with MPG.