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Updated: Jul 18, 2026

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
Published on: January 24, 2018
A simple automated solution for removing and applying sealing microplate lids
G A Clarke1, M N Feiglin, G W King
1Department of Research Operations, Merck Research Laboratories, Rahway, NJ 07065, USA. glenn_clarke@merck.com
Abstract:
With the improved reliability and efficiency of automation, there has been an increased desire to integrate automated sample management with automated screening systems. In order to store samples "on line" for an extended period of time, an automation-compatible means for sealing and unsealing microplates is necessary. Numerous commercial solutions are available for removing loose-fitting microplate lids; however, the task of removing a tight-fitting matted lid such as the RoboLid is more challenging. This paper discusses the design of an automated workstation for the application and removal of such tight-fitting microplate lids.

