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Recombinant Newcastle disease virus as a vaccine vector
1Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Journal of Virology
|November 2, 2001
Abstract:
A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.