Related Experiment Video
Updated: Oct 3, 2026

08:32
Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Interleukin-4 up-regulates mouse mammary tumor virus expression yet is not required for in vivo virus spread
J Czarneski1, J Meyers, T Peng
1Department of Microbiology, Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6142, USA.
Journal of Virology
|November 2, 2001
Abstract:
The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription. However, interleukin-4 is not required for in vivo virus spread, because mice lacking interleukin-4 or the STAT6 transcription factor showed wild-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.

