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Updated: Oct 3, 2026

Skin Tattooing As A Novel Approach For DNA Vaccine Delivery
Published on: October 18, 2012
Vaccination with attenuated simian immunodeficiency virus by DNA inoculation
1Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia. skent@unimelb.edu.au
Abstract:
Delivering attenuated lentivirus vaccines as proviral DNA would be simple and inexpensive. Inoculation of macaques with wild-type simian immunodeficiency virus strain mac239 (SIV(mac239)) DNA or SIV(mac239) DNA containing a single deletion in the 3' nef-long terminal repeat overlap region (nef/LTR) led to sustained SIV infections and AIDS. Injection of SIV(mac239) DNA containing identical deletions in both the 5' LTR and 3' nef/LTR resulted in attenuated SIV infections and substantial protection against subsequent mucosal SIV(mac251) challenge.
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