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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Neurons: The Cell Body and the Dendrites01:23

Neurons: The Cell Body and the Dendrites

A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...

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Related Experiment Video

Updated: Jun 30, 2026

Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay
12:17

Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay

Published on: January 19, 2012

Stem cells find their niche.

A Spradling1, D Drummond-Barbosa, T Kai

  • 1HHMI/Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA.

Nature
|November 2, 2001
PubMed
Summary
This summary is machine-generated.

Stem cell niches, specific microenvironments controlling stem cells, are moving from theory to reality. New techniques allow scientists to study these niches in organs like the skin and gut, advancing stem cell therapy.

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Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay
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Published on: January 19, 2012

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Area of Science:

  • Stem Cell Biology
  • Developmental Biology
  • Tissue Engineering

Background:

  • The concept of stem cell niches as regulatory microenvironments is well-established but largely theoretical.
  • Identifying and manipulating stem cells and their niches has been a significant challenge in the field.

Purpose of the Study:

  • To explore the transition of stem cell niches from a theoretical construct to an experimentally tractable entity.
  • To highlight how recent technical advancements enable the characterization of stem cell niches.
  • To discuss the implications for understanding stem cell regulation and therapeutic applications.

Main Methods:

  • Characterization of specific microenvironmental zones controlling stem cell activity.
  • Investigating stem cell niches in various organs, including gonads, skin, and gut.
  • Utilizing advanced techniques for identifying and manipulating individual stem cells and their niche components.

Main Results:

  • Technical advances now permit the detailed study of stem cell niches.
  • Stem cell niches have been successfully identified and characterized in key organs.
  • These studies are beginning to reveal the cellular and molecular mechanisms of stem cell regulation within niches.

Conclusions:

  • Stem cell niches are becoming experimentally accessible, moving beyond a theoretical concept.
  • Understanding stem cell niches at the cellular and molecular levels is advancing.
  • The study of stem cell niches holds significant promise for future therapeutic strategies in regenerative medicine.