Related Experiment Video
Updated: Jun 30, 2026

Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay
Published on: January 19, 2012
Stem cells find their niche
A Spradling1, D Drummond-Barbosa, T Kai
1HHMI/Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA.
Abstract:
The concept that stem cells are controlled by particular microenvironments known as 'niches' has been widely invoked. But niches have remained largely a theoretical construct because of the difficulty of identifying and manipulating individual stem cells and their surroundings. Technical advances now make it possible to characterize small zones that maintain and control stem cell activity in several organs, including gonads, skin and gut. These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically.
Related Concept Videos
Adult Stem Cells
Determination
Stem Cell Niche
Multipotency and Niche of Bulge Stem Cell
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Neurons: The Cell Body and the Dendrites

