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Serum amylase changes during pregnancy.

R Kaiser, J E Berk, L Fridhandler

    American Journal of Obstetrics and Gynecology
    |June 1, 1975
    PubMed
    Summary
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    Serum amylase activity increases during pregnancy, potentially exceeding normal levels in the second and third trimesters. Salivary amylase may dominate, important for diagnosing pancreatitis in pregnant women.

    Area of Science:

    • Biochemistry
    • Obstetrics
    • Clinical Chemistry

    Background:

    • Serum amylase levels are commonly monitored in clinical diagnostics.
    • Pregnancy involves significant physiological changes that can affect various biochemical markers.
    • Understanding normal physiological variations is crucial for accurate disease diagnosis.

    Purpose of the Study:

    • To investigate the behavior of serum amylase activity throughout pregnancy.
    • To compare serum amylase levels in pregnant women with nonpregnant individuals and men.
    • To examine changes in isoamylase distribution during pregnancy.

    Main Methods:

    • Serum amylase activity was measured in 200 pregnant women at various gestational stages.
    • Isoamylase types (pancreatic and salivary) were analyzed.

    Related Experiment Videos

  • Data were compared between pregnant women, nonpregnant women, and men.

    • Main Results:

    • Serum amylase activity gradually increased until the 25th week of pregnancy, followed by a slight decrease.
    • Elevated serum amylase values, exceeding those in normal men and nonpregnant women, were observed in the second and third trimesters.
    • A shift towards salivary-type isoamylase dominance was noted during the second trimester.

    Conclusions:

    • Pregnancy-induced changes in serum amylase activity and isoamylase distribution are significant.
    • These physiological variations must be considered in the clinical assessment of pregnant women, particularly when evaluating symptoms suggestive of acute pancreatitis.
    • Further research is needed to elucidate the underlying mechanisms for these observed changes.