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Updated: Jul 20, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
Published on: July 14, 2015
Primary sequences of proteinlike copolymers: Levy-flight-type long-range correlations
E N Govorun1, V A Ivanov, A R Khokhlov
1Physics Department, Moscow State University, Moscow 119899, Russia.
Abstract:
We consider the statistical properties of primary sequences of two-letter HP copolymers (H for hydrophobic and P for polar) designed to have water soluble globular conformations with H monomers shielded from water inside the shell of P monomers. We show, both by computer simulations and by exact analytical calculation, that for large globules and flexible polymers such sequences exhibit long-range correlations which can be described by Levy-flight statistics.
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