Related Experiment Video
Updated: Oct 3, 2026

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
Published on: June 24, 2015
Synchronization of hyperexcitable systems with phase-repulsive coupling
G Balázsi1, A Cornell-Bell, A B Neiman
1Center for Neurodynamics, University of Missouri-St Louis, 8001 Natural Bridge Road, St Louis, Missouri 63121-4499, USA.
Abstract:
We study two-dimensional arrays of FitzHugh-Nagumo elements with nearest-neighbor coupling from the viewpoint of synchronization. The elements are diffusively coupled. By varying the diffusion coefficient from positive to negative values, interesting synchronization patterns are observed. The results of the simulations resemble the intracellular oscillation patterns observed in cultured human epileptic astrocytes. Three measures are proposed to determine the degree of synchronization (or coupling) in both the simulated and the experimental system.
Related Concept Videos
Neural Circuits
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Action Potential: Phases of Stimulation
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
¹H NMR: Long-Range Coupling
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene π orbitals.
¹H NMR Signal Multiplicity: Splitting Patterns
Overview of Synapses
Pharmacodynamic Models: Link Model and Systems Pharmacodynamic Model

