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Updated: Aug 10, 2026

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting
Published on: February 21, 2014
Self-assembly of amphiphiles into vesicles: a Brownian dynamics simulation
1Department of Applied Molecular Science, Institute for Molecular Science, Okazaki 444-8585, Japan. noguchi@ims.ac.jp
Abstract:
We studied the vesicles of amphiphilic molecules using a Brownian dynamics simulation. An amphiphilic molecule is modeled as the rigid rod, and the hydrophobic interaction is mimicked by the local density potential of the hydrophobic particles. The amphiphilic molecules self-assemble into vesicles with bilayer structure. The vesicles are in fluid phase, and we calculated the lateral diffusion constant and the rate of the flip-flop motion of molecules in vesicles. The self-assembly kinetics into vesicles was also investigated.
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