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Related Experiment Videos

Neurological problems affecting hand dexterity.

M Wiesendanger1, D J Serrien

  • 1Laboratory of Motor Systems, Department of Neurology, University of Berne, Inselspital, BHH-M130, CH-3010, Berne, Switzerland. mario.wiesendanger@insel.ch

Brain Research. Brain Research Reviews
|November 3, 2001
PubMed
Summary
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Grip force regulation is impaired in movement disorders. Patients with hemiparesis, cerebellar disease, Huntington's Chorea, and writer's cramp exhibit altered grip force coordination, often using less flexible default strategies.

Area of Science:

  • Neuroscience
  • Biomechanics
  • Motor Control

Background:

  • Grip force and load force coordination is crucial for dexterous manipulation.
  • Movement disorders often involve deficits in motor control and force regulation.

Purpose of the Study:

  • To review the coordination of grip and load forces.
  • To summarize the pathophysiology of grasping in various movement disorders.

Main Methods:

  • Analysis of grip force regulation during a drawer-pulling task with perturbed loads.
  • Comparison of force coordination in healthy subjects versus patients with hemiparesis, cerebellar disease, Huntington's Chorea, and writer's cramp.

Main Results:

  • Healthy subjects proactively increase grip force with expected load.

Related Experiment Videos

  • Hemiparetic patients fail to generate proactive grip force, leading to slips.
  • Cerebellar patients use a high grip force default strategy.
  • Huntington's Chorea and writer's cramp patients exhibit overscaled grip force, suggesting altered sensorimotor integration.

    • Conclusions:

    • Cortical and subcortical pathologies degrade manual dexterity.
    • Movement disorders may lead to the adoption of less flexible, default force regulation strategies.
    • Altered sensorimotor integration contributes to impaired grip force control in writer's cramp.