Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitochondrial disease and stroke.

E Martínez-Fernández1, A Gil-Peralta, R García-Lozano

  • 1Stroke and Neuromuscular Units, Department of Neurology, Hospital Universitario Virgen del Rocío, Sevilla, Spain. med010426@nacom.es

Stroke
|November 3, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low aerobic capacity in McArdle disease: A role for mitochondrial network impairment?

Molecular metabolism·2022
Same author

Recurrent bilateral asynchronous cellulitis: Report of two cases and a literature review.

Archivos de la Sociedad Espanola de Oftalmologia·2022
Same author

Recurrent bilateral asynchronous cellulitis: Report of two cases and a literature review.

Archivos de la Sociedad Espanola de Oftalmologia·2020
Same author

Regenerative plasticity of intact human skin axons.

Journal of the neurological sciences·2020
Same author

Paracoccidiodomycosis lung reactivation in a patient with signet-ring cell gastric adenocarcinoma after chemotherapy: Case report.

IDCases·2020
Same author

Kink far below the Fermi level reveals new electron-magnon scattering channel in Fe.

Nature communications·2019

In young patients, ischemic stroke may be the sole or initial sign of a mitochondrial disorder. Further investigation revealed specific mitochondrial DNA mutations in a subset of these patients.

Area of Science:

  • Neurology
  • Mitochondrial Diseases
  • Genetics

Background:

  • Mitochondrial disorders are known causes of ischemic cerebral infarction in young individuals.
  • This study investigated whether ischemic stroke is the exclusive manifestation of mitochondrial disorders in this demographic.

Observation:

  • Eighteen patients under 50 with unexplained ischemic stroke were assessed.
  • Diagnostic procedures included biochemical tests, neuroimaging, echocardiography, Doppler sonography, and forearm exercise tests for lactic acid.
  • Biceps muscle biopsies were analyzed for morphological, biochemical, and molecular changes.

Findings:

  • 17% of patients exhibited lactic acid overproduction post-exercise.
  • 33% displayed deficits in mitochondrial respiratory chain complexes.

Related Experiment Videos

  • Confirmed mitochondrial DNA mutations (3243, 4216, 15928), including one characteristic of MELAS.

    • Implications:

    • Ischemic stroke can be the sole presenting symptom of a mitochondrial disorder.
    • Early identification of mitochondrial disorders is crucial in young stroke patients.
    • Findings highlight the importance of mitochondrial investigations in cryptogenic stroke.