Related Experiment Video
Updated: Aug 11, 2026
11:49
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
IL-17 expression as a possible predictive parameter for subclinical renal allograft rejection
Summary
Interleukin-17 (IL-17) plays a key role in subclinical renal allograft rejection. Early detection of IL-17 in animal models and human biopsies may predict borderline rejection, aiding transplant management.
Area of Science:
- Immunology
- Transplantation Medicine
- Nephrology
Background:
- Subclinical renal allograft rejection poses a diagnostic challenge.
- Early detection markers are crucial for timely intervention in kidney transplantation.
Purpose of the Study:
- To investigate the role of Interleukin-17 (IL-17) in subclinical renal allograft rejection.
- To assess IL-17 as a potential predictive marker for borderline renal allograft rejection.
Main Methods:
- Heterotopic renal transplantation in a rat model (BN to LEW).
- Histopathological examination and Banff classification.
- Quantification of IL-17 mRNA and antigen expression.
- Analysis of human renal biopsy and urinary sediment samples.
Main Results:
- IL-17 mRNA and antigen expression were elevated early in rat renal allografts with borderline changes.
- IL-17 was detected in human borderline rejected allografts but not in normal controls.
- IL-17 mRNA was found in urinary sediment of patients with subclinical rejection.
Conclusions:
- IL-17 emerges as an early indicator of subclinical renal allograft rejection.
- IL-17 holds potential as a predictive biomarker for borderline renal allograft rejection.
- Further validation may lead to improved monitoring of kidney transplant recipients.
