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Related Concept Videos

The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Cells Coordinate Growth and Proliferation02:36

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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
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Related Experiment Video

Updated: Jun 27, 2026

Live Cell Imaging of Chromosome Segregation During Mitosis
06:39

Live Cell Imaging of Chromosome Segregation During Mitosis

Published on: March 14, 2018

[When chromosomal dynamics control cell division].

M Peter1, L Magnaghi-Jaulin, A Castro

  • 1Centre de recherche de biochimie macromoléculaire, CNRS UPR 1086, 1919, route de Mende, 34293 Montpellier, France.

Pathologie-Biologie
|November 6, 2001
PubMed
Summary
This summary is machine-generated.

The mitotic checkpoint prevents aneuploidy by delaying cell division when chromosomes are misaligned. This ensures accurate chromosome segregation, crucial for preventing cancer development.

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Last Updated: Jun 27, 2026

Live Cell Imaging of Chromosome Segregation During Mitosis
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Area of Science:

  • Cell Biology
  • Genetics
  • Cancer Research

Background:

  • Chromosomal instability and aneuploidy are hallmarks of most tumor cells.
  • The mitotic checkpoint is vital for accurate chromosome segregation during cell division.
  • This checkpoint delays mitosis until all chromosomes are correctly aligned on the spindle.

Purpose of the Study:

  • To explain the function of the mitotic checkpoint in preventing aneuploidy.
  • To highlight the conserved nature of the spindle checkpoint pathway across eukaryotes.
  • To describe the molecular mechanism by which the checkpoint inhibits the anaphase-promoting complex/cyclosome (APC).

Main Methods:

  • Identification of genes involved in mitotic delay in Saccharomyces cerevisiae (MAD, BUB, MPS1).
  • Identification of homologous genes in higher eukaryotes.
  • Description of the conserved spindle checkpoint pathway.

Main Results:

  • The mitotic checkpoint delays anaphase onset when chromosomes are unattached to the spindle.
  • Homologs of key checkpoint genes (MAD, BUB, MPS1) are conserved in higher eukaryotes.
  • The checkpoint prevents APC-mediated ubiquitination and degradation of proteins required for anaphase.

Conclusions:

  • The conserved mitotic checkpoint is essential for maintaining genomic stability by ensuring accurate chromosome segregation.
  • Dysfunction of this checkpoint can lead to aneuploidy and potentially contribute to tumorigenesis.
  • Understanding this pathway provides insights into cancer development and potential therapeutic targets.