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[Lip-jaw-palate clefts. Heterogenous disease pictures]
E Kunstmann1, J Radtke, J T Epplen
1Molekulare Humangenetik, Ruhr-Universität Bochum, Universitätsstrasse 150, 44801 Bochum. erdmute.kunstmann@ruhr-uni-bochum.de
Mund-, Kiefer- Und Gesichtschirurgie : MKG
|November 6, 2001
Abstract
Background:
Orofacial clefts are congenital structural deficits involving the lip with or without the palate. The genetic origins of orofacial clefts have been considered as heterogeneous for a long time. Non-syndromatic clefts are based on complex traits.
Discussion:
The different approaches towards the genetics of this multifactorial disease are discussed and the consequences for genetic counselling for patients, persons at risk and their relatives are reflected upon.