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Updated: Jul 28, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Catechol-O-methyltransferase (COMT) genetic polymorphism in a Turkish population
N A Kocabaş1, A E Karakaya, S Cholerton
1Department of Toxicology, Faculty of Pharmacy, Gazi University, Hipodrom-Ankara, Turkey. neslihanak@hotmail.com
Genetic variations in Catechol-O-methyltransferase (COMT) affect neurotransmitter levels. This study found COMT gene frequencies in Turkish individuals align with Caucasians, differing from Oriental populations.
Area of Science:
- Pharmacogenetics
- Neuroscience
- Biochemistry
Background:
- Catechol-O-methyltransferase (COMT) is crucial for inactivating neurotransmitters and catechol hormones.
- A common genetic variation (G to A transition) leads to a valine-to-methionine substitution, affecting COMT activity.
- Previous studies noted ethnic and inter-individual differences in COMT activity.
Purpose of the Study:
- To investigate the inter-individual variability of COMT genotype in the Turkish population.
- To compare COMT allelic frequencies in Turks with other ethnic groups.
Main Methods:
- Genotyping of 217 healthy, unrelated Turkish individuals.
- Analysis of allelic frequencies for the COMT gene.
Main Results:
- The allelic frequencies of the COMT gene in the Turkish population were determined.
- Turkish COMT genotype frequencies were found to be similar to Caucasian populations.
- Significant differences were observed when compared to Oriental populations.
Conclusions:
- The genetic profile of COMT in the Turkish population resembles that of Caucasians.
- This study provides the first data on COMT genotype variability in the Turkish population.
- Understanding these variations is important for pharmacogenetics and personalized medicine.
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