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One-pot synthesis of cinnamylamines with various protecting groups from cinnamyl ethers
1Sungkyunkwan University, Organic & Medicinal Chemistry Laboratory, College of Pharmacy, Suwon 440-746, Kyonggi-Do, Korea. yhjung@skku.ac.kr
Archives of Pharmacal Research
|November 6, 2001
Abstract:
The reaction of various alkyl cinnamyl ethers with CSI afforded the corresponding cinnamylamines with various protecting groups, such as -NHMoc, -NHiPoc, -NHCbz, -NHPnz, -NHTroc and -NHAloc. In the case of cinnamyl t-butyl ether and cinnamyl p-methoxybenzyl ether, the corresponding cinnamyl carbamates were formed via a different reaction pathway from the above.