Related Experiment Video
Updated: Jul 20, 2026
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Coronary artery stenting in the aged
M S Chauhan1, R E Kuntz, K L Ho
1Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. mchauhan@caregroup.harvard.edu
Journal of the American College of Cardiology
|November 6, 2001
Summary
Coronary artery stenting is safe for patients aged 80 and older, showing good acute results and low restenosis. However, aged patients face higher risks of mortality and bleeding complications.
Area of Science:
- Cardiology
- Interventional Cardiology
- Geriatric Medicine
Background:
- Limited data exist on coronary artery stenting outcomes in patients aged 80 years and older.
- This study addresses the safety and efficacy gap in this specific demographic.
Purpose of the Study:
- To compare the safety and efficacy of coronary artery stenting in aged (≥80 years) versus nonaged patients.
- To identify predictors of adverse clinical outcomes in this patient population.
Main Methods:
- A pooled analysis of 6,186 patients from six multicenter trials undergoing coronary artery stenting.
- Clinical endpoints were adjudicated by a committee, and quantitative angiography was performed by an independent core laboratory.
Main Results:
- Aged patients (4.9%) had higher rates of multivessel disease, unstable angina, and calcification.
- Procedural success was similar, but aged patients experienced significantly higher in-hospital and one-year mortality, and bleeding complications.
- Clinical restenosis rates were comparable between aged and nonaged groups.
Conclusions:
- Coronary artery stenting is feasible in patients aged 80 and older, with favorable acute outcomes and low restenosis.
- Despite good procedural success, aged patients face increased risks of mortality and complications, necessitating careful consideration.
More Related Videos
05:04Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access
Published on: November 19, 2020
07:25Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
01:26Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
01:26Coronary Artery Disease IV: Preventive Measures
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
01:27Coronary Artery Disease V: Interprofessional Care
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
01:26Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
01:27Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...