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Type B1 thymoma in multiple endocrine neoplasia type 1 (MEN-1) syndrome
G De Toma1, M Plocco, V Nicolanti
1Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Italy. detoma@uniroma1.it
Aims And Background:
Multiple endocrine neoplasia (MEN) syndromes include a group of disorders characterized by the neoplastic transformation of two or more endocrine tissues. In type 1 syndrome (MEN-1), pituitary, parathyroid and pancreatic islet tumors are most frequently represented. Thymic neoplasms are also rarely associated, and thymectomy during subtotal or total parathyroidectomy should always be considered.
Study Design:
The authors describe a rare case of a 22-year-old male who presented a type B1 thymoma without myasthenia gravis associated to hyperparathyroidism, corticoadrenal adenoma and three neuroendocrine pancreatic lesions (somatostatinoma, glucagonoma and insulinoma).
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