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Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
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Association between myeloperoxidase levels and risk of coronary artery disease

R Zhang1, M L Brennan, X Fu

  • 1Department of Cell Biology, Cleveland Clinic Foundation, 9500 Euclid Ave, NC-10, Cleveland, OH 44195, USA.

JAMA
|November 22, 2001
PubMed
Abstract

Insights

Elevated myeloperoxidase (MPO) levels in blood and leukocytes are strongly associated with coronary artery disease (CAD). This suggests MPO may be a key inflammatory marker for diagnosing and assessing atherosclerosis risk.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Inflammation Studies

Background:

  • Myeloperoxidase (MPO) is a leukocyte enzyme implicated in lipoprotein oxidation within atheromas.
  • MPO's role as a potential mediator in the development of atherosclerosis has been previously suggested.

Purpose of the Study:

  • To investigate the association between myeloperoxidase (MPO) levels and the prevalence of coronary artery disease (CAD).

Main Methods:

  • A case-control study was conducted involving 158 patients with established CAD and 175 controls without significant CAD.
  • MPO levels were measured per milligram of neutrophil protein (leukocyte-MPO) and per milliliter of blood (blood-MPO).
  • Associations with CAD risk were analyzed using multivariable models, adjusting for cardiovascular risk factors.

Main Results:

  • Both leukocyte-MPO and blood-MPO levels were significantly higher in patients with CAD compared to controls (P<.001).
  • Adjusted analyses revealed significant associations between MPO levels and CAD presence.
  • The highest quartiles of leukocyte-MPO and blood-MPO showed odds ratios of 11.9 and 20.4, respectively, for CAD.

Conclusions:

  • Elevated leukocyte-MPO and blood-MPO levels are significantly associated with the presence of coronary artery disease.
  • These findings support MPO's role as an inflammatory marker in CAD.
  • MPO may hold implications for improving atherosclerosis diagnosis and risk stratification.

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