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Circulating fetal DNA in maternal plasma.

L L Poon¹, Y M Lo

¹Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Room 38023, 1/F Clinical Sciences Building, 30-32 Ngan Shing Street Shatin, New Territories, SAR, Hong Kong, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|November 6, 2001

Summary

High concentrations of fetal DNA in maternal plasma offer potential for non-invasive prenatal diagnosis. This finding is expected to become a standard part of prenatal care for pregnant women soon.

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Area of Science:

Genetics
Molecular Biology
Obstetrics

Background:

Circulating fetal DNA is present in maternal plasma at high concentrations.
This presence opens possibilities for non-invasive prenatal diagnostic methods.

Purpose of the Study:

To explore the applications of fetal DNA in maternal plasma for clinical diagnosis.
To highlight the potential of this biomarker in prenatal care.

Main Methods:

Analysis of fetal DNA in maternal plasma.
Review of existing and potential clinical applications.

Main Results:

Confirmation of high concentrations of circulating fetal DNA in maternal plasma.
Identification of numerous applications for clinical diagnosis.

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Conclusions:

Fetal DNA in maternal plasma is a promising tool for non-invasive prenatal diagnosis.
It is anticipated to become a routine component of prenatal investigations in the near future.