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Related Experiment Videos

Mucosal drug delivery.

V H Lee1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles 90089-9121, USA. vincentL@hsc.usc.edu

Journal of the National Cancer Institute. Monographs
|November 6, 2001
PubMed
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This review explores epithelial drug transport in mucosal delivery, focusing on the intestinal dipeptide transporter PepT1. This transporter is key for targeting drugs to tumor cells, with less known about oral cavity drug absorption.

Area of Science:

  • Pharmacology
  • Cell Biology
  • Drug Delivery

Background:

  • Mucosal drug delivery involves epithelial transport, crucial for oral cavity and gastrointestinal tract absorption.
  • Cytotoxic chemotherapeutic drugs often cause side effects in these mucosae.
  • Carrier-mediated transport is a key mechanism in mucosal drug absorption.

Purpose of the Study:

  • To review epithelial drug transport mechanisms in mucosal drug delivery.
  • To highlight the role of the intestinal dipeptide transporter PepT1 in this process.
  • To compare drug transport in the gastrointestinal tract versus the oral cavity.

Main Methods:

  • Literature review focusing on carrier-mediated transport and PepT1.
  • Analysis of PepT1's presence and robustness in tumor epithelial cells.

Related Experiment Videos

  • Comparison of drug transport knowledge between gastrointestinal and buccal mucosae.

    • Main Results:

    • The intestinal dipeptide transporter PepT1 is enriched in tumor epithelial cells.
    • PepT1 is relatively resistant to cytotoxic chemotherapeutic drugs.
    • PepT1 shows potential for molecular engineering of targeted cancer drugs.
    • Drug transport in buccal epithelial cells is less understood than in the gastrointestinal tract.

    Conclusions:

    • PepT1 is a promising target for developing chemotherapeutic drugs with enhanced efficacy and reduced side effects.
    • Further research is needed to understand and optimize drug transport in the buccal mucosa for therapeutic applications.