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A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

Early-onset neonatal sepsis in the era of group B streptococcal prevention

R S Baltimore1, S M Huie, J I Meek

  • 1Department of Pediatrics, Emerging Infections Program, Yale University School of Medicine, New Haven, Connecticut 06520-8064, USA. robert.baltimore@yale.edu

Pediatrics
|November 6, 2001
PubMed

Insights

Intrapartum antibiotic prophylaxis for group B streptococcal (GBS) disease did not increase non-GBS or antibiotic-resistant neonatal infections. Continued surveillance is recommended due to fluctuating E. coli resistance rates.

Area of Science:

  • Neonatal infectious diseases
  • Public health surveillance
  • Antibiotic resistance

Background:

  • Intrapartum antibiotic prophylaxis (IAP) is used to prevent neonatal group B streptococcal (GBS) disease.
  • Concerns exist regarding potential increases in non-GBS or antibiotic-resistant infections due to IAP.

Purpose of the Study:

  • To evaluate the impact of IAP on the incidence of non-GBS and antibiotic-resistant early-onset invasive neonatal diseases.

Main Methods:

  • Chart review of infants with non-GBS bacteria in blood or spinal fluid from 1996-1999 in Connecticut.
  • Inclusion criteria: isolation of bacteria other than GBS from blood or spinal fluid.

Main Results:

  • The rate of GBS infections decreased significantly.
  • The annual rate of non-GBS sepsis remained stable.
  • Ampicillin resistance in E. coli showed fluctuations but no sustained increase.

Conclusions:

  • IAP did not lead to an increase in non-GBS early-onset neonatal infections.
  • Ongoing surveillance is necessary to monitor E. coli infections and antibiotic resistance.
Abstract

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