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Prenatally diagnosed microcephaly: a review of etiologies
1University of British Columbia Division of Maternal Fetal Medicine, B.C. Women's Hospital, Vancouver, B.C., Canada.
Objective:
To determine the incidence and etiology of prenatally diagnosed microcephaly.
Methods:
Retrospective review of 10 years at a tertiary obstetrical hospital. The study population consisted of 21 infants with confirmed prenatal and postnatal microcephaly.
Results:
There were 8 different definite/probable etiologies identified (viral, monochorionic twinning, genetic syndrome, neural tube defect, abnormal karyotype, hypoxic insult, constitutional).
Conclusions:
Retrospective study indicates the commonest etiologies for prenatal microcephaly are in utero infection, monochorionic twin insult, rare genetic syndrome and chromosomal anomalies.