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[Primary thyroid lymphoma: report of 8 cases]
M Paccalin1, D Gouet, V Ribouleau
1Service de médecine interne endocrinologie, CHU La Milétrie, rue de La Milétrie, 86021 Poitiers, France. m.paccalin@chu-poitiers.fr
La Revue De Medecine Interne
|November 7, 2001
Summary
Primary thyroid lymphoma (PTL) is rare. Combined surgery, chemotherapy, and radiotherapy offer good long-term remission for PTL patients, with recent thyroid enlargement suggesting diagnosis.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Primary thyroid lymphoma (PTL) is an uncommon malignancy.
- Limited case reports exist, necessitating further clinical insights.
Observation:
- Eight PTL cases with long-term follow-up were analyzed.
- Typical presentation involves an enlarging neck mass causing compressive symptoms.
- Diagnosis confirmed via thyroidectomy, histopathology, and immunohistochemistry.
Findings:
- Chronic lymphocytic thyroiditis infiltrates observed in all cases.
- Three cases of mucosa-associated lymphoid tissue (MALT) lymphoma identified.
- One patient experienced a postoperative fatality.
- Seven patients achieved sustained remission for over 6 years with combined modality treatment (chemotherapy and radiotherapy).
Implications:
- Recent thyroid enlargement warrants suspicion for PTL.
- Multimodal therapy (surgery, chemotherapy, radiation) demonstrates efficacy for PTL management.
- This approach yields favorable long-term outcomes, contrasting with some prior recommendations emphasizing non-surgical management.