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Effects of 2 inhaled corticosteroids on growth: results of a randomized controlled trial

F M de Benedictis1, A Teper, R J Green

  • 1Clinica Pediatrica, Policlinico Monteluce, 06100 Perugia, Italy. debened@unipg.it

Archives of Pediatrics & Adolescent Medicine
|November 29, 2001
PubMed

Insights

Fluticasone propionate showed significantly greater growth velocity in children with asthma compared to beclomethasone dipropionate. This suggests fluticasone is a preferred long-term treatment option for pediatric asthma management.

Area of Science:

  • Pediatric Pulmonology
  • Pharmacology
  • Clinical Research

Background:

  • Inhaled corticosteroids (ICS) are standard therapy for persistent asthma in children.
  • Long-term effects of different ICS on growth are a critical consideration for pediatric use.

Purpose of the Study:

  • To compare the long-term effects of fluticasone propionate (FP) versus beclomethasone dipropionate (BDP) on growth in prepubertal children with asthma.

Main Methods:

  • A prospective, multicenter, randomized, double-blind, parallel-group study.
  • 277 children (aged 4-11 years) with asthma received either FP or BDP (200 mcg twice daily) via dry powder inhaler for 12 months.
  • Growth velocity, lung function, and cortisol levels were assessed.

Main Results:

  • Fluticasone propionate group exhibited significantly greater adjusted mean growth velocity (5.01 cm/y) compared to the beclomethasone dipropionate group (4.10 cm/y).
  • Both ICS improved lung function, with FP showing a statistically significant advantage.
  • No significant differences in adverse events or cortisol levels were observed between the groups.

Conclusions:

  • Fluticasone propionate demonstrates a more favorable risk-benefit profile than beclomethasone dipropionate for long-term asthma treatment in children.
  • FP is recommended over BDP for pediatric asthma, particularly when moderate doses are necessary.
Abstract

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