Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The proteasome and its function in the ageing process.

A Stolzing1, T Grune

  • 1Neuroscience Research Center, Medical Faculty, Charité, Humboldt University Berlin, Germany.

Clinical and Experimental Dermatology
|November 7, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary Inflammatory Index and Cross-Sectional Associations with Inflammation, Muscle Mass and Function in Healthy Old Adults.

The journal of nutrition, health & aging·2022
Same author

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains.

Scientific reports·2021
Same author

Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation.

Archives of toxicology·2018
Same author

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

Redox biology·2017
Same author

Generation of human induced pluripotent stem cells using non-synthetic mRNA.

Stem cell research·2016
Same author

Effect of systemic transplantation of bone marrow-derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice.

Neuropathology and applied neurobiology·2016
Same journal

The evolving understanding of prurigo nodularis.

Clinical and experimental dermatology·2026
Same journal

Cutaneous inflammatory biomarkers in rosacea and their association with disease severity.

Clinical and experimental dermatology·2026
Same journal

A slowly enlarging pink nodular lesion with arborizing vessels on the scalp.

Clinical and experimental dermatology·2026
Same journal

Guselkumab for checkpoint inhibitor-exacerbated psoriasis in a patient with metastatic melanoma.

Clinical and experimental dermatology·2026
Same journal

Real-World Outcomes of Stapokibart-Based Combination Therapy for Bullous Pemphigoid: A Single-Center Retrospective Cohort.

Clinical and experimental dermatology·2026
Same journal

A second case of recessive mosaicism in ABCA12 causing a congenital unilateral epidermal nevus.

Clinical and experimental dermatology·2026
See all related articles

Oxidative damage from reactive oxygen species contributes to aging by impairing protein function. The proteasomal system degrades these damaged proteins, but its own function during aging is a key area of study.

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Gerontology

Background:

  • Aging involves progressive functional decline.
  • Reactive oxygen species (ROS) are implicated in aging via oxidative damage.
  • Oxidative protein damage leads to dysfunction and degradation.

Purpose of the Study:

  • To review current knowledge on proteasome activity during aging.
  • To explore the proteasomal system's involvement in the aging process.
  • To understand the role of oxidative stress in proteasome function.

Main Methods:

  • Literature review of studies on proteasome activity and aging.
  • Analysis of research on oxidative damage to proteins.
  • Examination of the proteasomal system's role in protein degradation.

Related Experiment Videos

Main Results:

  • Oxidative modification of proteins causes dysfunction.
  • The proteasomal system is the primary machinery for degrading oxidized proteins.
  • Proteasomes are conserved but also susceptible to oxidative stress.

Conclusions:

  • The proteasomal system plays a critical role in managing oxidative damage during aging.
  • Further research is needed to fully elucidate the proteasome's involvement in aging.
  • Understanding proteasome function may offer insights into age-related decline.