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Respiratory complications during anaesthesia in Apert syndrome
T Elwood1, P V Sarathy, J M Geiduschek
1Department of Anesthesiology, University of Washington School of Medicine, WA 98105-0371, USA. telwoo@chmc.org
Paediatric Anaesthesia
|November 7, 2001
Summary
Anesthesia for Apert syndrome patients frequently leads to respiratory complications like wheezing. Preoperative albuterol did not show benefits, highlighting the need for awareness among pediatric anesthesiologists.
Area of Science:
- Anesthesiology
- Pediatric Surgery
- Genetics
Background:
- Apert syndrome is a rare genetic disorder characterized by craniosynostosis, midface hypoplasia, and syndactyly.
- Clinical experience with anesthesia in Apert syndrome patients is not well-documented.
Purpose of the Study:
- To report clinical experience with anesthesia in patients with Apert syndrome.
- To identify anesthetic-related complications in this patient population.
Main Methods:
- A retrospective review of 10 years of anesthetic records was conducted.
- Data from 145 anesthetics administered to 18 individuals with Apert syndrome were analyzed.
Main Results:
- A high incidence of respiratory complications was observed, with 16 complications in 7 patients.
- Fifteen complications involved perioperative wheezing, and four surgeries were canceled due to intractable wheezing.
Conclusions:
- Preoperative nebulized albuterol did not demonstrate a significant benefit in preventing respiratory complications.
- Pediatric anesthesiologists must be aware of the high risk of respiratory complications in patients with Apert syndrome.