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Cardiomyopathy Caused by Antineoplastic Therapies
Valeriano C. Simbre II1, M. Jacob Adams, Sampada S. Deshpande
1Divisions of Cardiology and Gastroenterology/Nutrition, Department of Pediatrics, and Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 631, Rochester, NY 14642, USA. steve_lipshultz@urmc.rochester.edu
Current Treatment Options in Cardiovascular Medicine
|November 7, 2001
Summary
Cancer treatments can cause heart problems like cardiomyopathy. Early detection and management of cardiac dysfunction are key to improving survival and quality of life for at-risk patients.
Area of Science:
- Cardiology
- Oncology
- Pharmacology
Background:
- Cancer therapies, such as chemotherapy, can lead to cardiotoxicity.
- Cardiomyopathy is a significant concern for patients undergoing cancer treatment, impacting survival and quality of life.
Purpose of the Study:
- To outline goals of care for cancer treatment-induced cardiomyopathy.
- To discuss strategies for minimizing cardiotoxic effects while maintaining cancer treatment efficacy.
- To review current treatment approaches for established cancer therapy-related cardiomyopathy.
Main Methods:
- Literature review of cardiotoxicity in cancer patients.
- Analysis of treatment strategies balancing oncologic efficacy and cardiac safety.
- Summary of diagnostic and therapeutic interventions for cancer therapy-related cardiomyopathy.
Main Results:
- Goals of care include prevention, early diagnosis, and management of cardiac dysfunction.
- Limiting cumulative doses (e.g., Doxorubicin) can reduce cardiotoxicity.
- Standard heart failure treatments (e.g., ACE inhibitors, beta-blockers) are used for symptomatic patients.
Conclusions:
- A multidisciplinary approach is essential for managing cancer therapy-induced cardiomyopathy.
- Optimizing quality of life involves balancing cancer treatment effectiveness with cardiac toxicity.
- Cardiac transplantation is an option for end-stage heart disease in these patients.