Related Experiment Video

Updated: Aug 3, 2026

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures
10:01

Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures

Published on: March 12, 2018

'Facilitated' PCI for Acute MI: PCI with Lysis and Platelet Inhibition

Warren J. Cantor1, E. Magnus Ohman

  • 1Division of Cardiology, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada. cantorw@smh.toronto.on.ca

Current Interventional Cardiology Reports
|November 7, 2001
PubMed

Insights

Facilitated percutaneous coronary intervention (PCI) combines thrombolysis with GP IIb/IIIa inhibitors and early PCI. This approach may offer superior reperfusion and outcomes for acute myocardial infarction patients compared to traditional methods.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Emergency Medicine

Background:

  • Reperfusion therapy is critical for acute myocardial infarction (AMI) to restore blood flow.
  • Primary percutaneous coronary intervention (PCI) offers better reperfusion than thrombolysis alone.
  • Glycoprotein (GP) IIb/IIIa inhibitors enhance outcomes in both primary PCI and thrombolysis.

Purpose of the Study:

  • To evaluate the safety and efficacy of 'facilitated' PCI in patients with acute myocardial infarction.
  • To assess the combination of pharmacologic and mechanical reperfusion strategies for AMI management.

Main Methods:

  • Review of recent studies on early PCI after thrombolysis.
  • Analysis of 'facilitated' PCI strategies combining low-dose thrombolysis, GP IIb/IIIa inhibition, and early PCI with stenting.
  • Evaluation of ongoing clinical trials assessing facilitated PCI.

Main Results:

  • Early PCI with stenting after low-dose thrombolysis and GP IIb/IIIa inhibition appears safe and effective.
  • Facilitated PCI combines the rapid benefits of thrombolysis with the high patency rates of primary PCI.
  • Ongoing trials are investigating the optimal role of facilitated PCI in AMI.

Conclusions:

  • Facilitated PCI represents a promising strategy for acute myocardial infarction management.
  • This approach integrates pharmacologic and mechanical reperfusion for potentially superior clinical outcomes.
  • Further evaluation in ongoing trials will determine the definitive role of facilitated PCI in AMI treatment.

More Related Videos

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

Related Concept Videos

Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...