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Updated: Jul 12, 2026

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
Published on: December 10, 2021
n-3 Polyunsaturated fatty acids, fish, and nonfatal acute myocardial infarction
A Tavani1, C Pelucchi, E Negri
1Istituto di Ricerche Farmacologiche "Mario Negri", Istituto di Statistica Medica e Biometria, Università degli Studi di Milano, Milan, Italy. tavani@marionegri.it
Background:
The relation between n-3 polyunsaturated fatty acids (PUFAs), fish intake, and risk of coronary heart disease is controversial.
Methods And Results:
An Italian case-control study including 507 patients with nonfatal acute myocardial infarction (AMI) and 478 hospital controls found a multivariate odds ratio (OR) of 0.67 (95% CI, 0.47 to 0.95) for the highest n-3 PUFA intake and 0.68 (95% CI, 0.47 to 0.98) for an intake of >1 portion of fish per week compared with >/=2 portions per week.
Conclusions:
Small amounts of n-3 PUFAs may be inversely related to AMI risk in this low-risk population.
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