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Non-transferrin-bound iron in alcohol abusers.
T M De Feo1, S Fargion, L Duca
1Dipartimento di Medicina Interna, Università di Milano, Milano, Italy.
Alcoholism, Clinical and Experimental Research
|November 7, 2001
Summary
Non-transferrin-bound iron (NTBI) is prevalent in active alcohol abusers, particularly those with liver cirrhosis. Alcohol intake and bilirubin levels are independently associated with NTBI, suggesting its role in alcohol-induced liver damage.
Area of Science:
- Hepatology
- Biochemistry
- Toxicology
Background:
- Non-transferrin-bound iron (NTBI) is a low-molecular-weight iron complex known to induce free radical formation and lipid peroxidation.
- NTBI has been identified in alcohol-fed animals, but its presence in human alcohol abusers with liver disease remains uninvestigated.
Purpose of the Study:
- To determine if NTBI is present in chronic alcohol abusers with liver involvement.
- To investigate the association between alcohol consumption and the appearance of NTBI.
Main Methods:
- NTBI levels were measured in a cohort of chronic alcohol abusers (n=43 active, n=33 abstainers) and during follow-up.
- Patients were assessed at presentation, with stratification based on alcohol abuse status and presence of liver cirrhosis.
- Transferrin saturation levels were also evaluated.
Main Results:
- NTBI was detected in 83.7% of active alcohol abusers versus 21.2% of abstainers.
- Alcohol abusers with cirrhosis exhibited significantly higher NTBI levels compared to those without cirrhosis.
- Alcohol intake and total bilirubin were independently associated with NTBI levels, irrespective of transferrin saturation.
Conclusions:
- NTBI is frequently present in chronic alcohol abusers, especially those with liver disease.
- Alcohol consumption and elevated bilirubin are key factors contributing to NTBI accumulation.
- NTBI may play a significant role in the pathogenesis of alcohol-induced liver injury.