Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal outcome 25 years after donor nephrectomy.

D A Goldfarb1, S F Matin, W E Braun

  • 1Urological Institute and Department of Hypertension/Nephrology Cleveland Clinic Foundation, Cleveland, Ohio, USA.

The Journal of Urology
|November 7, 2001
PubMed
Summary

Kidney donation is safe long-term, with renal function well-preserved 25 years post-nephrectomy. While some protein excretion increases, it poses no clinical risk for most kidney donors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-IL-6R Ab tocilizumab to treat paraneoplastic inflammatory syndrome of solid cancers.

ESMO open·2025
Same author

Somatic profile in lung cancers is associated to reproductive factors in never-smokers women: Results from the IFCT-1002 BioCAST study.

Respiratory medicine and research·2020
Same author

Association of Candidate Removals From the Kidney Transplant Waiting List and Center Performance Oversight.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Management of malignant pleural mesothelioma: a French multicenter retrospective study (GFPC 0802 study).

BMC cancer·2015
Same author

Critical Factors Associated With Missing Follow-Up Data for Living Kidney Donors in the United States.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Effect of dialysis initiation for preemptively listed candidates in the revised kidney allocation policy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2014

Area of Science:

  • Nephrology
  • Transplantation Surgery
  • Urology

Background:

  • Long-term donor renal outcome is crucial due to hyperfiltration injury concerns.
  • Limited data exists on kidney donor outcomes beyond 20 years post-donation.

Purpose of the Study:

  • To assess the long-term impact of donor nephrectomy on renal function.
  • To evaluate urinary protein excretion and hypertension development in kidney donors after 20 years.

Main Methods:

  • Retrospective study of 70 live kidney donors from 1963-1975.
  • Assessed 24-hour creatinine clearance, serum creatinine, and urinary protein/albumin.
  • Compared postoperative values with pre-donation baseline and age-adjusted norms.

Main Results:

Related Experiment Videos

  • Mean follow-up was 25 years; creatinine clearance decreased to 72% of pre-donation levels.
  • Serum creatinine and systolic blood pressure increased but remained within normal ranges.
  • Males showed higher urinary protein/albumin excretion; proteinuria generally had no clinical consequence.

Conclusions:

  • Renal function is well-preserved in most kidney donors at long-term follow-up (mean 25 years).
  • Males exhibit higher proteinuria, but no significant clinical differences in renal function or blood pressure were observed.
  • Pre-existing mild proteinuria may indicate a risk for future significant proteinuria in donors.