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Noncircumferential myofiber function: impact on early diastolic filling in children

E C Michelfelder1, P Khoury, S A Witt

  • 1Noninvasive Cardiac Imaging and Hemodynamic Research Laboratory, Division of Cardiology, Children's Hospital Medical Center, 3333 Burnet Ave., OSB-4, Cincinnati, OH 45229, USA. miche0@chmcc.org

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|November 7, 2001
PubMed

Insights

Oblique myofiber shortening, measured by left ventricular systolic twist (LVST), significantly impacts early diastolic filling in children. This contrasts with circumferential and longitudinal shortening, which showed no relation to diastolic function.

Area of Science:

  • Pediatric Cardiology
  • Cardiac Physiology
  • Echocardiography

Background:

  • Myofiber contraction patterns influence systolic and diastolic function.
  • Understanding noncircumferential fiber mechanics is crucial for assessing global left ventricular function.

Purpose of the Study:

  • To investigate the relationship between circumferential, longitudinal, and oblique left ventricular (LV) fiber shortening and early diastolic filling in children.
  • To determine the impact of LV systolic twist (LVST) on pediatric diastolic function.

Main Methods:

  • Prospective echocardiographic evaluation in 25 healthy children (mean age 8.1 years).
  • Assessment of circumferential (shortening fraction, fractional area change), longitudinal (axial shortening), and oblique (LVST) fiber shortening.
  • Measurement of early diastolic filling parameters, including E-wave acceleration time.

Main Results:

  • No significant correlation was found between early diastolic filling indexes and circumferential or longitudinal shortening.
  • A significant inverse relationship was observed between heart rate-corrected E-wave acceleration time and LVST (r = 0.63, P <.001).

Conclusions:

  • Oblique fiber shortening, specifically LVST, plays a role in early diastolic filling in pediatric populations.
  • Further research into noncircumferential myofiber function can enhance the understanding of overall left ventricular function.

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