Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adolescent familial cramps.

P A Hanson, J E Mincy

    Neurology
    |May 1, 1975
    PubMed
    Summary

    This study investigated a novel familial myopathy in adolescent brothers experiencing exercise-induced leg cramps. Elevated creatine phosphokinase levels and muscle biopsy changes suggest a genetic muscle disorder peaking during adolescence.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Restoration of endodontically treated teeth with posts and cores.

    Journal of the Irish Dental Association·2000
    Same author

    Magnetic resonance imaging of fourth ventricular epidermoid tumors.

    Archives of neurology·1991
    Same author

    Diet for control of the ileoanal reservoir.

    Ostomy/wound management·1990
    Same author

    Perianal skin care for persons with an ileoanal reservoir.

    Ostomy/wound management·1990
    Same author

    Intradural extramedullary ependymoma: MR-pathologic correlation.

    Journal of computer assisted tomography·1988
    Same author

    Treatment of amyotrophic lateral sclerosis with the TRH analog DN-1417.

    Neurology·1987

    Area of Science:

    • Neurology
    • Genetics
    • Muscle Diseases

    Background:

    • Familial leg cramps after exercise in adolescents.
    • Potential genetic basis for muscle disorders.

    Purpose of the Study:

    • Investigate a novel familial myopathy.
    • Characterize symptoms and progression in adolescents.

    Main Methods:

    • Clinical examination of affected individuals.
    • Serum creatine phosphokinase level analysis.
    • Muscle biopsy for histopathological examination.

    Main Results:

    • Adolescent brothers presented with exercise-induced leg cramps.
    • Significant elevations in serum creatine phosphokinase observed.
    • Muscle biopsies showed myopathic changes.
    • All seven siblings exhibited elevated creatine phosphokinase, peaking in adolescence.

    Conclusions:

    • A familial myopathy with maximal penetrance during adolescence is suggested.
    • This disorder may represent a new form of myopathy.
    • Further research into the genetic and molecular basis is warranted.