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Updated: Aug 10, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Quantitative structure-activity relationship of some HIV-1 protease inhibitors: a Fujita-Ban type analysis
S B Mekapati1, R Sivakumar, S P Gupta
1Department of Chemistry, Pomona College, Claremont, CA 91711, USA.
Abstract:
A Fujita-Ban type analysis has been made on a few series of HIV-1 (human immunodeficiency virus of type 1) protease inhibitors and the activity contributions of various substituents obtained. From these activity contributions, a compound is predicted that may have better activity than ritonavir, presently prescribed for the treatment of patients suffering from HIV-1. A few other compounds are also suggested.
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