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2'-Deoxycoformycin for hepatosplenic gammadelta T-cell lymphoma
1Department of Clinical Haematology and Medical Oncology, The Royal Melbourne Hospital, Parkville, Victoria, Australia. andrew.grigg@mh.org.au
Leukemia & Lymphoma
|November 8, 2001
Abstract:
We describe a patient with unusually indolent hepatosplenic gammadelta T cell lymphoma characterised by severe lassitude and high fever. No significant responses were obtained to a range of chemotherapeutic and biological agents. 2'-deoxycoformycin (dCF), however, produced a dramatic and sustained clinical and histological response. This is the second recent report of gammadelta T cell lymphoma responding to dCF, suggesting this agent may have a specific role in this condition.