Related Experiment Video
Updated: Aug 12, 2026
12:09
A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
Published on: June 16, 2013
Angiogenesis in acute and chronic leukemias
1Department of Medicine, University of Utah and SLC VA Medical Centers, Salt Lake City 84148, USA.
Leukemia & Lymphoma
|November 8, 2001
Summary
Angiogenesis, the formation of new blood vessels, is crucial in leukemia development and progression. Research is exploring angiogenesis inhibitors as a potential new leukemia treatment.
Area of Science:
- Oncology
- Hematology
Background:
- Angiogenesis is vital for solid tumor growth.
- Emerging evidence implicates angiogenesis in leukemia pathophysiology.
- Increased bone marrow angiogenesis and elevated angiogenic factors are observed in leukemia patients.
Purpose of the Study:
- To review the role of angiogenesis in leukemia.
- To discuss the potential role of vascular endothelial growth factor (VEGF) in acute myeloid leukemia (AML).
- To highlight the need for further research on angiogenesis and VEGF as prognostic factors and therapeutic targets in leukemia.
Main Methods:
- Literature review of studies on angiogenesis in leukemia.
- Analysis of evidence linking angiogenic factors, including VEGF, to leukemia.
- Examination of ongoing research into angiogenesis inhibitors for leukemia treatment.
Main Results:
- Significant evidence supports increased angiogenesis in acute and chronic leukemias.
- Vascular endothelial growth factor (VEGF) is suggested to act as an autocrine growth factor in AML.
- The prognostic significance of angiogenesis and VEGF in leukemia requires further validation.
Conclusions:
- Angiogenesis is a key factor in leukemia.
- VEGF may play a critical role in AML.
- Angiogenesis inhibitors represent a promising area for leukemia therapy investigation.
Related Concept Videos
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
01:10Mechanism of Angiogenesis
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
01:24Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
01:26Acute Inflammation II: Cellular Phase
The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...
01:12Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...