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Related Experiment Video

Updated: Jul 18, 2026

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Laser Capture Microdissection of Mouse Embryonic Cartilage and Bone for Gene Expression Analysis

Published on: December 18, 2019

Chromosome 13 locus, Pbd2, regulates bone density in mice.

M Shimizu¹, K Higuchi, S Kasai

¹Department of Orthopedic Surgery, Faculty of Medicine, Kyoto University, Japan.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research

|November 8, 2001

Summary

Researchers identified a specific gene region on chromosome 13 (Pbd2 locus) that significantly influences peak bone density in mice. This finding helps understand the genetic basis of osteoporosis and bone mass regulation.

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Area of Science:

Genetics
Osteoporosis Research
Animal Models

Background:

Bone density is a complex polygenic trait.
Previous studies identified QTLs on Chr 11 and 13 for peak relative bone mass.
The SAMP6 strain, a model for senile osteoporosis, has lower peak relative bone mass than SAMP2.

Purpose of the Study:

To investigate the effects of the Chr 13 QTL on peak bone density (Pbd2).
To dissect the complex polygenic trait of bone density into single gene factors.

Main Methods:

Construction of a congenic strain (P6.P2-Pbd2b) with a Chr 13 interval from SAMP2 on an SAMP6 background.
Measurement of bone density using three methods with different principles.
Haplotype analysis of senescence-accelerated mouse (SAM) strains around the Pbd2 locus.

Main Results:

The congenic strain exhibited higher bone density than the background strain.
A specific haplotype associated with high bone mass was identified in the Pbd2 locus.
Alleles from an unknown strain correlated with high bone mass, while AKR/J alleles correlated with low bone mass.

Conclusions:

The Pbd2 locus on chromosome 13 plays a significant role in regulating peak bone density in SAM strains.
This study confirms a specific genetic locus influencing bone density, contributing to the understanding of osteoporosis genetics.