Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Opioids in chronic pain.

R Przewłocki1, B Przewłocka

  • 1Department of Molecular Neuropharmacology, Institute of Pharmacology, 12 Smetna Street, 31-343 Kraków, Poland. nfprzewl@cyf-kr.edu.pl

European Journal of Pharmacology
|November 8, 2001
PubMed
Summary

Opioid peptides and their receptors play a key role in pain management. Novel peptides like endomorphins show promise for treating neuropathic pain, offering new therapeutic avenues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain.

Neuropharmacology·2019
Same author

Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model.

Neuroscience·2015
Same author

Behavioral and molecular alterations in mice resulting from chronic treatment with dexamethasone: relevance to depression.

Neuroscience·2014
Same author

Temporal and anatomic patterns of immediate-early gene expression in the forebrain of C57BL/6 and DBA/2 mice after morphine administration.

Neuroscience·2014
Same author

Genotype-dependent consequences of traumatic stress in four inbred mouse strains.

Genes, brain, and behavior·2012
Same author

Common transcriptional effects in the mouse striatum following chronic treatment with heroin and methamphetamine.

Genes, brain, and behavior·2012

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Research

Background:

  • Endogenous opioid peptides (enkephalins, dynorphins, beta-endorphin) and their receptors are crucial for pain modulation.
  • Recent discoveries include endomorphins and the pronociceptin system, expanding the understanding of opioid signaling.
  • Opioid receptors (mu, delta, kappa) are G-protein coupled receptors involved in antinociception.

Purpose of the Study:

  • To explore the role of opioid peptide systems in chronic pain.
  • To investigate the impact of inflammation on opioid efficacy.
  • To understand the mechanisms underlying opioid action in neuropathic pain.

Main Methods:

  • Review of existing literature on opioid peptide biogenesis, distribution, and receptor interactions.
  • Analysis of studies on opioid effects in animal models of inflammatory and neuropathic pain.
  • Examination of molecular changes in opioid systems during inflammation and nerve injury.

Main Results:

  • Peripheral inflammation enhances the antinociceptive potency of opioids, particularly mu-opioid receptor agonists.
  • Inflammation alters opioid receptor expression and gene expression in the spinal cord.
  • Neuropathic pain models show reduced efficacy of traditional opioids like morphine, but endomorphins appear effective.

Conclusions:

  • Opioid systems are significantly involved in pain processing, with inflammation modulating their effects.
  • Neuropathic pain exhibits reduced sensitivity to systemic opioids, necessitating higher doses.
  • Endomorphins represent a potential therapeutic target for neuropathic pain due to their efficacy in preclinical models.

Related Experiment Videos